Laboratory of structure and functions of mitochondria

A. N. Belozersky Research Institute of Physico-Chemical Biology MSU


Our team

Плотников Егор Юрьевич

Reactive oxygen and nitrogen species: friends or foes?

Mitochondrial regulation of production of reactive oxygen species and nitrogen in rat cells of kidney during ischemia/reperfusion.

Functional activity of mitochondria in cultured neural precursor cells.

Functional aftereffects of intraparenchymatous injection of human fetal stem and progenitor cells to rats with chronic and acute renal failure.

The mitochondrion as janus bifrons.

Effects of ischemic and hypoxic preconditioning on the state of mitochondria and function of ischemic kidneys.

Experimental intravenous cell therapy of acute and chronic renal failure.

The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney.

Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons.

Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: protective effects of SkQ1, lithium ions and insulin.

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture.

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke).

Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia.

Myoglobin causes oxidative stress, increase of NO production and dysfunction of kidney's mitochondria.

Heterogeneity of mitochondrial potential as a marker for isolation of pure cardiomyoblast population.

Effect of xenotransplantation of cell cultures enriched with stem and progenitor cells on hormonal profile of rats with abdominal cryptorchism.

Morphological changes in the kidneys of rats with postischemic acute renal failure after intrarenal administration of fetal mesenchymal stem cells from human bone marrow.

Effect of transitory glucose deprivation on mitochondrial structure and functions in cultured cerebellar granule neurons.

New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties.

Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture.

Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion.

Inhibition of GSK-3β decreases the ischemia-induced death of renal cells.

Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies.

Human induced pluripotent stem cells derived from fetal neural stem cells successfully undergo directed differentiation into cartilage.

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.

The phenoptosis problem: what is causing the death of an organism? Lessons from acute kidney injury.

Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family.

The mitochondria-targeted antioxidants and remote kidney preconditioning ameliorate brain damage through kidney-to-brain cross-talk.

N-terminally glutamate-substituted analogue of gramicidin A as protonophore and selective mitochondrial uncoupler.

Inflammatory pre-conditioning of mesenchymal multipotent stromal cells improves their immunomodulatory potency in acute pyelonephritis in rats.

Methods of detection of mesenchymal stem cells in the kidneys during therapy of experimental renal pathologies.

Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity.

Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection.

Perspectives of mitochondrial medicine.

Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention.

[Molecular mechanisms of ischemic-reperfusion syndrome and its personalized therapy].

The mitochondrion as a key regulator of ischaemic tolerance and injury.

Lithium salts -- simple but magic.

Neuroprotective effect of glutamate-substituted analog of gramicidin A is mediated by the uncoupling of mitochondria.

Microbiota and mitobiota. Putting an equal sign between mitochondria and bacteria.

[Pathological changes after brain ischemia are similar to those observed in Alzheimer disease].

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.

Mitodiversity.

Intercellular Transfer of Mitochondria.

Magnetic resonance spectroscopy of the ischemic brain under lithium treatment. Link to mitochondrial disorders under stroke.

A mitochondria-targeted protonophoric uncoupler derived from fluorescein.

A model Ni-Al-Mo superalloy studied by ultraviolet pulsed-laser-assisted local-electrode atom-probe tomography.

Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation With Cortical Neurons: The Role of Crosstalk Between Cells.

Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury.

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury.

Intramitochondrial accumulation of cationic Atto520-biotin proceeds via voltage-dependent slow permeation through lipid membrane.

Diseases and Aging: Gender Matters.

CHANGES IN THE NUMBER OF NEURONS, ASTROCYTES AND MICROGLIA IN THE BRAIN AFTER ISCHEMIC STROKE ASSESSED BY IMMUNOHISTOCHEMISTRY AND IMMUNOBLOTTING.

QUANTIFICATION OF MITOCHONDRIAL MORPHOLOGY IN SITU.

Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia.

The role of myoglobin degradation in nephrotoxicity after rhabdomyolysis.

Do Mitochondria Have an Immune System?

Mechanisms of Inflammatory Injury of Renal Tubular Cells in a Cellular Model of Pyelonephritis.

Dysfunction of Kidney Endothelium after Ischemia/Reperfusion and Its Prevention by Mitochondria-Targeted Antioxidant.

Molecular and Cellular Interactions between Mother and Fetus. Pregnancy as a Rejuvenating Factor.

Intercellular Signalling Cross-Talk: To Kill, To Heal and To Rejuvenate.

The Use of Technetium-99m for Intravital Tracing of Transplanted Multipotent Stromal Cells.

The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy.

A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector.

Mitochondrial membrane potential.

The role of oxidative stress in acute renal injury of newborn rats exposed to hypoxia and endotoxin.

The Influence of Proinflammatory Factors on the Neuroprotective Efficiency of Multipotent Mesenchymal Stromal Cells in Traumatic Brain Injury.

Effect of Anesthetics on Efficiency of Remote Ischemic Preconditioning.

Mitochondrial Aging: Is There a Mitochondrial Clock?

Bacterial Therapy and Mitochondrial Therapy.

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery.

Comparative Study of the Severity of Renal Damage in Newborn and Adult Rats under Conditions of Ischemia/Reperfusion and Endotoxin Administration.

Aged kidney: can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning.

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic⁻Ischemic Brain Injury.

Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats.

Pregnancy protects the kidney from acute ischemic injury.

Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury.

Effect of Silk Fibroin on Neuroregeneration After Traumatic Brain Injury.

Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies.

Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update.

Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation.

Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury.

Mitochondria as a Source and a Target for Uremic Toxins.

Lost or Forgotten: The nuclear cathepsin protein isoforms in cancer.

Zwitterionic Protonophore Derived from 2-(2-Hydroxyaryl)alkenylphosphonium as an Uncoupler of Oxidative Phosphorylation.

Pros and Cons of Use of Mitochondria-Targeted Antioxidants.

Rapamycin Is Not Protective against Ischemic and Cisplatin-Induced Kidney Injury.

Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.

Mitochondria in the Nuclei of Rat Myocardial Cells.

Microbiome-Metabolome Signature of Acute Kidney Injury.

A Combination of Kidney Ischemia and Injection of Isolated Mitochondria Leads to Activation of Inflammation and Increase in Mortality Rate in Rats.

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia.

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.

Nonphosphorylating Oxidation in Mitochondria and Related Processes.

Linking 7-Nitrobenzo-2-oxa-1,3-diazole (NBD) to Triphenylphosphonium Yields Mitochondria-Targeted Protonophore and Antibacterial Agent.

Targeting Inflammation and Oxidative Stress as a Therapy for Ischemic Kidney Injury.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells.

Dietary Restriction for Kidney Protection: Decline in Nephroprotective Mechanisms During Aging.

Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons.

Mechanisms Underlying the Protective Effect of the Peroxiredoxin-6 Are Mediated via the Protection of Astrocytes during Ischemia/Reoxygenation.

Ischemic Preconditioning of the Kidney.

Effects of Panthenol and N-Acetylcysteine on Changes in the Redox State of Brain Mitochondria under Oxidative Stress In Vitro.

The Mechanisms Underlying the Protective Action of Selenium Nanoparticles against Ischemia/Reoxygenation Are Mediated by the Activation of the Ca<sup>2+</sup> Signaling System of Astrocytes and Reactive Astrogliosis.

Bioenergetics of the Fibrosis.

The Protective Mechanism of Deuterated Linoleic Acid Involves the Activation of the Ca<sup>2+</sup> Signaling System of Astrocytes in Ischemia In Vitro.

Gut Microbiota as a Source of Uremic Toxins.

Is the Mitochondrial Membrane Potential (∆Ψ) Correctly Assessed? Intracellular and Intramitochondrial Modifications of the ∆Ψ Probe, Rhodamine 123.

Features of the cytoprotective effect of selenium nanoparticles on primary cortical neurons and astrocytes during oxygen-glucose deprivation and reoxygenation.

Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism.

Dietary restriction modulates mitochondrial DNA damage and oxylipin profile in aged rats.

Hormonal Regulation of Renal Fibrosis.

Anti-Inflammatory Properties of Metformin During Cultivation of Primary Rat Astrocytes in a Medium with High Glucose Concentration.

Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?

Size-Dependent Cytoprotective Effects of Selenium Nanoparticles during Oxygen-Glucose Deprivation in Brain Cortical Cells.

Human Multipotent Mesenchymal Stromal Cell-Derived Extracellular Vesicles Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury.

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations.

Effects of Ketogenic Diet on Muscle Metabolism in Health and Disease.

Age-Associated Loss in Renal Nestin-Positive Progenitor Cells.

Development of an In Vitro Model of SARS-CoV-Induced Acute Lung Injury for Studying New Therapeutic Approaches.

Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury.

Cytoprotective Properties of a New Nanocomplex of Selenium with Taxifolin in the Cells of the Cerebral Cortex Exposed to Ischemia/Reoxygenation.

Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments.

Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats.

Neuronal Calcium Sensor-1 Protects Cortical Neurons from Hyperexcitation and Ca<sup>2+</sup> Overload during Ischemia by Protecting the Population of GABAergic Neurons.

New experimental model of kidney injury: Photothrombosis-induced kidney ischemia.

Ketogenic Diet and Ketone Bodies against Ischemic Injury: Targets, Mechanisms, and Therapeutic Potential.

Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1.

The Ketogenic Diet but not Hydroxycitric Acid Keeps Brain Mitochondria Quality Control and mtDNA Integrity Under Focal Stroke.

The Relationship of p62 Gene Expression with Integrity of Mitochondrial DNA and the Level of Lipid Peroxidation Products in Skeletal Muscles of Rats of Different Ages Exposed to Different Feeding Protocols.

The Role of Matrix Metalloproteinases in Hemorrhagic Transformation in the Treatment of Stroke with Tissue Plasminogen Activator.

Pilot Study of Cytoprotective Mechanisms of Selenium Nanorods (SeNrs) under Ischemia-like Conditions on Cortical Astrocytes.

Decreased renal expression of PAQR5 is associated with the absence of a nephroprotective effect of progesterone in a rat UUO model.

Fibrosis Development Linked to Alterations in Glucose and Energy Metabolism and Prooxidant-Antioxidant Balance in Experimental Models of Liver Injury.

Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen-Glucose Deprivation through Activation of the Ca<sup>2+</sup> Signaling System.

Mitochondrial Network: Electric Cable and More.

Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR.

Effects of caloric restriction and ketogenic diet on renal fibrosis after ischemia/reperfusion injury.

Noncoupled Mitochondrial Respiration as Therapeutic Approach for the Treatment of Metabolic Diseases: Focus on Transgenic Animal Models.

The effects of antibiotic therapy on neonatal sepsis-associated acute kidney injury.

Selenium Nanoparticles in Protecting the Brain from Stroke: Possible Signaling and Metabolic Mechanisms.

Lactate protects neurons and astrocytes against ischemic injury by modulating Ca<sup>2+</sup> homeostasis and inflammatory response.

Anti-Inflammatory Effect of Synaptamide in Ischemic Acute Kidney Injury and the Role of G-Protein-Coupled Receptor 110.

Mitocentricity.

Relationship of Cytotoxic and Antimicrobial Effects of Triphenylphosphonium Conjugates with Various Quinone Derivatives.

Sex-Specific Effects of Estradiol and Progesterone in Ischemic Kidney Injury.

Neuroprotective Effects of Krypton Inhalation on Photothrombotic Ischemic Stroke.

Targeting Mitochondria for Cancer Treatment.

Beta-Hydroxybutyrate Mitigates Sensorimotor and Cognitive Impairments in a Photothrombosis-Induced Ischemic Stroke in Mice.

Effects of Lithium Ions on tPA-Induced Hemorrhagic Transformation under Stroke.

TLR3-mediated Astrocyte Responses in High and Normal Glucose Adaptation Differently Regulated by Metformin.

Differences in the Effect of Beta-Hydroxybutyrate on the Mitochondrial Biogenesis, Oxidative Stress and Inflammation Markers in Tissues from Young and Old Rats.

Impact of Intermittent Fasting and Dietary Restriction on Redox State, Energetic Metabolism, and Liver Injury in Common Bile Duct Ligation Model.

Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy.

Regulatory Role and Cytoprotective Effects of Exogenous Recombinant SELENOM under Ischemia-like Conditions and Glutamate Excitotoxicity in Cortical Cells In Vitro.

Analysis of the brain transcriptome, microbiome and metabolome in ketogenic diet and experimental stroke.

Positive Effects of Argon Inhalation After Traumatic Brain Injury in Rats.

New magnetic iron nanoparticle doped with selenium nanoparticles and the mechanisms of their cytoprotective effect on cortical cells under ischemia-like conditions.

Hemorrhagic Shock and Mitochondria: Pathophysiology and Therapeutic Approaches.

Cardiac titin isoforms: Practice in interpreting results of electrophoretic analysis.

L-Carnitine and Mildronate Demonstrate Divergent Protective Effects on Mitochondrial DNA Quality Control and Inflammation Following Traumatic Brain Injury.

Methylene Blue Protects Spatial Working Memory after Traumatic Brain Injury in Mice by Affecting Mitochondrial Quality Control System.

Deacetylase Inhibitor Trichostatin A Promotes the Proliferation of Epithelial Cells and Suppresses Glycolytic Activity of Fibroblasts in the Kidney.

Adaptive and Pathological Changes of the Cardiac Muscle in a Mouse Model of Renocardiac Syndrome: The Role of Nestin-Positive Cells.

Comparison of Glucose and Glutamine as Energy Substrates for Astrocytes under Conditions of Oxygen Deficiency.

Therapeutic modulation of energy metabolism in ischemic brain injury.

Organ-Specific Extracellular Vesicles in the Treatment of Ischemic Acute Organ Injury: Mechanisms, Successes, and Prospects.

Comparative Analysis of the Tolerance of Young and Old Kidneys to Injury in a Rat Model of Reversible Ureteral Obstruction.

Succinate Confers Stronger Cytoprotection in Kidney Cells than in Astrocytes Due to Its More Efficient Involvement in Energy Metabolism.

Special Issue "Advances in the Prevention and Treatment of Ischemic Diseases".